CALCIUM DOBESILATE – PROMISING ROLE IN VASCULAR DISORDERS & HEMORRHOIDS. Calcium Dobesilate is a Capillotropic, Venotropic and Vasculoprotective Agent A Multi- Faceted Mechanism of Action
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A randomized, double-blind multicentre clinical trial comparing the efficacy of calcium dobesilate with placebo in the treatment of chronic venous disease.
OBJECTIVE To assess the efficacy of calcium dobesilate on the quality-of-life (QoL) of patients with chronic venous disease (CVD). DESIGN Randomised, parallel, double blind, placebo-controlled clinical trial. METHODS Patients were recruited from vascular surgery clinics and randomised to 500mg capsules of calcium dobesilate twice a day for 3 months or placebo. The primary outcome measure wa...
متن کاملNegative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays
Previously, we reported the strong negative interference of calcium dobesilate, a vasoprotective agent, in creatinine assays involving the Trinder reaction. It is hypothesized that a similar effect occurs in the detection of uric acid (UA), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). The interferences...
متن کاملCalcium dobesilate may improve hemorheology in patients undergoing coronary artery bypass grafting.
BACKGROUND Calcium dobesilate is an angioprotective agent that has positive effects on hemorheological parameters. It is an antioxidant that increases endothelial-derived vasodilator substance secretion, there are none that analyze its effects during the postoperative period of patients undergoing myocardial revascularization. OBJECTIVE We aimed to determine the effects of calcium dobesilate ...
متن کاملEffect of calcium dobesilate on occurrence of diabetic macular oedema (CALDIRET study): randomised, double-blind, placebo-controlled, multicentre trial.
BACKGROUND Medical treatment for diabetic retinopathy could have an important role in prevention of complications such as visual loss. We aimed to assess the effect of calcium dobesilate on occurrence of diabetic macular oedema. METHODS We undertook a randomised, double-blind, placebo-controlled, multicentre study in 40 centres in 11 countries. We enrolled outpatients with adult-onset type 2 ...
متن کاملCalcium dobesilate for prevention of gentamicin-induced nephrotoxicity in rats.
INTRODUCTION Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicin-induced nephrotoxicity. MATERIAL AND METHODS This experimental study was conducted on 40 male Sprague-Dawley rats. The rats were randomly divided into the following 5 groups: control, sham, gentamicin (100 mg/kg/d, intraperitoneal), gentamicin and calci...
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تاریخ انتشار 2004